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Beatrice Cappio Flash

When reporting complication rates, only definite and probably attributable events occurring within 30 days will be include. Intervention Type. Sequential applications of up to 7 times per session cappio needle allowed for complete ablation of the lesions. Last Name. Responsible Party Type. Arm Group Label. EUS-FNI is a promising method to optimize treatment to a targeted area while minimizing procedure invasiveness and systemic toxicity. EUS-guided ablation, brachytherapy, fiducial marker placement, and antitumor agent injection have been described to date.


While these procedures appear to be safe and reasonably well tolerated, their effectiveness and exact role in oncological treatment cappio needle yet to be established. Since the introduction of endoscopic ultrasound EUS for the diagnosis and staging of gastrointestinal and pancreaticobiliary malignancies[ 1 ], EUS has increasingly been described as a therapeutic modality. The same minimal invasiveness and precision that favor EUS as a diagnostic modality have generated interest in its therapeutic potential.

EUS-guided celiac plexus neurolysis is now a well-accepted modality for palliation of pain in patients with pancreatic cancer, and EUS is now often used to facilitate bile duct identification and access during difficult endoscopic retrograde cholangiopancreatography ERCP [ 2 ]. More recently, the role of EUS fine needle injection EUS-FNI has expanded to include ablation of malignant or pre-malignant tissue, placement of brachytherapy and fiducial markers, and direct delivery of antitumor agents into a targeted lesion under ultrasonographic visualization, theoretically minimizing systemic exposure and increasing local concentration.

Injectable agents that have cappio needle described for this purpose include lymphocytic cultures, immature dendritic cells, and viral vectors, although most of these studies are limited by their small size, lack of control, and include patients with pancreatic cancer only[ 2 ]. Ethanol causes cell-membrane lysis and protein degeneration and has been proposed as a method of ablating the cyst-wall epithelium of premalignant lesions or malignant lesions in poor surgical candidates[ 3 ]. After initial cyst needle puncture, cyst fluid is partially aspirated and the cyst is lavaged for several minutes by alternating cyst aspiration and ethanol injection[ 4 ]. Ethanol ablation of pancreatic cystic lesions was first described by Gan et al[ 3 ] in in a study that included 13 patients with benign mucinous cystic neoplasms and 4 patients with intraductal papillary neoplasms.

Courtesy of Hendra and Agnes. Cappio needle applied radiofrequency ablation appears to be safe in the treatment of malignant biliary obstruction.


High operative risk of cool-tip radiofrequency ablation for unresectable cappio needle head cancer. J Surg Oncol. Zhonghua Yixue Zazhi. Endoscopic ultrasound guided radiofrequency ablation, for pancreatic cystic neoplasms and neuroendocrine tumors.

World J Gastrointest Surg. Feasibility and safety of EUS-guided cryothermal ablation in patients with locally advanced pancreatic cancer. Cappio needle focused ultrasound treatment of liver tumours: post-treatment MRI correlates well with intra-operative estimates of treatment volume.


Br J Radiol. Endoscopic high-intensity focused US: technical aspects and studies in an in cappio needle porcine model with video Gastrointest Endosc.

Endoscopic ultrasound-guided oncologic therapy for pancreatic cancer. Cappio needle trademarks are the property of their respective owners.

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A recent small prospective multi-center cappio needle study of EUS-RFA of pancreatic head neoplasms and neuroendocrine tumors was reported using a novel monopolar RF probe 1. Two patients suffered from mild abdominal pain but no serious adverse events reported. Thus, based on these preliminary results, we conclude that the new generation EUS-guided RFA probe is safe and feasible. The next stage in development with conduction of this study would involve recruitment of larger patient cohorts to further establish the efficacy and risk profile of the procedure.

The benefit may include RFA destroy the tumour cells via coagulative necrosis process hence providing some form of disease control. Besides, the current study could establish the safety and feasibility of EUS-guided RFA of solid pancreatic neoplasms. These results could provide insights as to whether the procedure is comparable to surgery for treatment of these lesions in the future. All trademarks are the property of their respective owners. The EUS-guided application of the Nd: Hirooka et al[ 4 ] conducted a trial where five patients with inoperable locally advanced enedle cancer were treated with intravenous gemcitabine and biweekly EUS guided immature dendritic cell injections, followed by intravenous infusion of lymphokine- activated killer cells stimulated with anti-CD3 monoclonal antibody CD3-LAKs.

Cappio, C. Soldati, M. Orsi, F. De Cobelli, M. However, the concept is promising. Current literature is cappio needle by small sample size, lack of control, and primarily includes patients with pancreatic cancer only. De Cobelli 1R.CAPPIO NEEDLE DRIVER - EUS-guided alcohol ablation of left adrenal metastasis from non-small-cell lung carcinoma. Side effects were mild and included. CAPPIO NEEDLE DRIVER - Prior studies have shown that dendritic cells exposed to tumor cells, when introduced to human subjects, generate a strong tumor.


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